Rxra^tm1Krc
Targeted Allele Detail

Summary

• Symbol: Rxra^tm1Krc
• Name: retinoid X receptor alpha; targeted mutation 1, Kenneth R Chien
• MGI ID: MGI:2385918
• Synonyms: RXRalpha^fl, RXRalphaflox, RXRalpha^floxed
• Gene: Rxra Location: Chr2:27566452-27652969 bp, + strand Genetic Position: Chr2, 19.38 cM
• Alliance: Rxra^tm1Krc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:48085
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was introduced into intron 3 and a floxed PGK-neo-tk cassette was introduced into intron 4 via homologous recombination. The PGK-neo-tk cassette was subsequently removed in correctly targeted cells by the transient expression of cre recombinase, leaving behind loxP sites flanking exon 4. (J:48085)

Disease models

Expression

In Mice Carrying this Mutation:	17 assay results 4 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	9 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Rxra^tm1Krc

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Rxra Mutation: 30 strains or lines available

References

• Original: J:48085 Chen J, et al., Ventricular muscle-restricted targeting of the RXRalpha gene reveals a non-cell-autonomous requirement in cardiac chamber morphogenesis. Development. 1998 May;125(10):1943-9
• All: 30 reference(s)