Nfe2l2^tm1Mym
Targeted Allele Detail

Summary

• Symbol: Nfe2l2^tm1Mym
• Name: nuclear factor, erythroid derived 2, like 2; targeted mutation 1, Masayuki Yamamoto
• MGI ID: MGI:2385925
• Synonyms: Nfe2l2^tm1Yin, nrf2 (-), Nrf2^-
• Gene: Nfe2l2 Location: Chr2:75505857-75534985 bp, - strand Genetic Position: Chr2, 44.75 cM
• Alliance: Nfe2l2^tm1Mym page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:41943
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A lacZ gene followed by a neomycin selection cassette was inserted in-frame into exon 5, and a 1.2 kb segment containing the rest of the exon 5 coding sequences was deleted. Northern blot analysis confirmed that no wild-type transcript is expressed from this allele. (J:41943)

Expression

In Mice Carrying this Mutation:	4 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	15 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Nfe2l2^tm1Mym

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 5 strains available Cell Lines: 0 lines available
• Carrying any Nfe2l2 Mutation: 90 strains or lines available

References

• Original: J:41943 Itoh K, et al., An Nrf2/small Maf heterodimer mediates the induction of phase II detoxifying enzyme genes through antioxidant response elements. Biochem Biophys Res Commun. 1997 Jul 18;236(2):313-22
• All: 347 reference(s)