Tg(Pbsn-cre)4Prb
Transgene Detail

Summary

• Symbol: Tg(Pbsn-cre)4Prb
• Name: transgene insertion 4, Pradip Roy-Burman
• MGI ID: MGI:2385927
• Synonyms: ARR2PB-Cre, PB-Cre, PbCre4, PB-Cre4
• Transgene: Tg(Pbsn-cre)4Prb Location: unknown
• Alliance: Tg(Pbsn-cre)4Prb page

Prostate hyperplasia and low-grade prostate intraepithelial neoplasia in Brca2^tm1Brn/Brca2^tm1Brn Tg(Pbsn-cre)4Prb/0 mice

Show the 9 phenotype image(s) involving this allele.

Transgene origin

• Strain of Origin: (C57BL/6 x DBA/2)F1

Transgene description

• Transgene Type: Transgenic (Recombinase)
• Mutation: Insertion
• Tg(Pbsn-cre)4Prb expression driven by 1 gene
  Transgene expression driven by:
  

  Organism

  Driver Gene

  Homolog in Mouse

  Note

  rat

  Pbsn (54193)

  Pbsn	(MGI:1860484)

• Mutation details: The transgene is composed of the cre recombinase gene under the control of a composite promoter derived from rat Pbsn. The rat Pbsn promoter drives postnatal transgene expression in the prostatic epithelium. The transgene is expressed postnatally in prostatic epithelium with the highest level of expression in the lateral lobe of the prostate gland. A very low level of transgene expression was detected in the seminal vesicles, testes, and ovaries. No transgene expression was detected in any of the other tissue types examined. (J:68167)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Pbsn (rat) Summary of all recombinase alleles driven by Pbsn. Comparative matrix view of recombinase activities Alliance rat Pbsn gene page

Disease models

Expression

In Mice Carrying this Mutation:

104044 assay results 6 RNA-Seq or microarray experiment(s)

Tumor Data

List all tumor models in MMHCdb carrying Tg(Pbsn-cre)4Prb

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available

References

• Original: J:68167 Wu X, et al., Generation of a prostate epithelial cell-specific Cre transgenic mouse model for tissue-specific gene ablation. Mech Dev. 2001 Mar;101(1-2):61-9
• All: 293 reference(s)