Nr2f1^tm1Mjts
Targeted Allele Detail

Summary

• Symbol: Nr2f1^tm1Mjts
• Name: nuclear receptor subfamily 2, group F, member 1; targeted mutation 1, Ming-Jer Tsai
• MGI ID: MGI:2385930
• Synonyms: COUP-TFI-, Coup-tfI mutant, mCOUP-TFI mutant
• Gene: Nr2f1 Location: Chr13:78337090-78346954 bp, - strand Genetic Position: Chr13, 41.38 cM
• Alliance: Nr2f1^tm1Mjts page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:42259
• Parent Cell Line: AB1 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Sequence encoding the amino terminus, the DNA binding domain, and a portion of the ligand binding domain was deleted by the insertion of neomycin selection cassette. Normal transcript was not detected by Northern blot analysis of homozygous mutant embryos. (J:42259)

Disease models

Expression

In Mice Carrying this Mutation:	29 assay results 2 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	11 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Nr2f1 Mutation: 25 strains or lines available

References

• Original: J:42259 Qiu Y, et al., Null mutation of mCOUP-TFI results in defects in morphogenesis of the glossopharyngeal ganglion, axonal projection, and arborization. Genes Dev. 1997 Aug 1;11(15):1925-37
• All: 17 reference(s)