Nr2f2^tm1Tsa
Targeted Allele Detail

Summary

• Symbol: Nr2f2^tm1Tsa
• Name: nuclear receptor subfamily 2, group F, member 2; targeted mutation 1, Sophia Y Tsai
• MGI ID: MGI:2385933
• Synonyms: COUP-TFII (-)
• Gene: Nr2f2 Location: Chr7:70001692-70016483 bp, - strand Genetic Position: Chr7, 38.66 cM
• Alliance: Nr2f2^tm1Tsa page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:54469
• Parent Cell Line: Other (see notes) (ES Cell)
• Strain of Origin: 129S7/SvEvBrd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Sequence encoding most the amino terminus, all of the DNA binding domain, and a portion of the ligand binding domain was replaced with a neomycin selection cassette. The absence of transcript was determined by RT-PCR analysis and in situ hybridization of homozygous mutant embryos. (J:54469)

Expression

In Structures Affected by this Mutation:

10 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Nr2f2 Mutation: 28 strains or lines available

Notes

ES cell line = AB1 (129S7/SvEvBrd-Hprt⁺) or AB2.2 (129S7/SvEvBrd-Hprt^b-m2).

References

• Original: J:54469 Pereira FA, et al., The orphan nuclear receptor COUP-TFII is required for angiogenesis and heart development. Genes Dev. 1999 Apr 15;13(8):1037-49
• All: 9 reference(s)