Nfe2l1^tm1Tow
Targeted Allele Detail

Summary

• Symbol: Nfe2l1^tm1Tow
• Name: nuclear factor, erythroid derived 2,-like 1; targeted mutation 1, Timothy Townes
• MGI ID: MGI:2385936
• Synonyms: Lcrf1^tm1uab, Nfe2l1^tm1Tmt
• Gene: Nfe2l1 Location: Chr11:96708240-96720794 bp, - strand Genetic Position: Chr11, 60.12 cM, cytoband D-E
• Alliance: Nfe2l1^tm1Tow page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:39447
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: 3.5 kb of genomic sequence containing exons 3, 4, 5 and part of 6 was replaced with a neomycin selection cassette. RT-PCR analysis on 8 day old embryoid bodies derived from homozygous ES cells confirmed that no transcript is expressed from this allele. (J:39447)

Expression

In Mice Carrying this Mutation:	3 assay results
In Structures Affected by this Mutation:	1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Nfe2l1 Mutation: 42 strains or lines available

References

• Original: J:39447 Farmer SC, et al., The bZIP transcription factor LCR-F1 is essential for mesoderm formation in mouse development. Genes Dev. 1997 Mar 15;11(6):786-98
• All: 4 reference(s)