Pdlim3^tm1Dsb
Targeted Allele Detail

Summary

• Symbol: Pdlim3^tm1Dsb
• Name: PDZ and LIM domain 3; targeted mutation 1, David S Bredt
• MGI ID: MGI:2385940
• Gene: Pdlim3 Location: Chr8:46338498-46372585 bp, + strand Genetic Position: Chr8, 25.86 cM
• Alliance: Pdlim3^tm1Dsb page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:67358
• Parent Cell Line: JM-1 (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 1, which encodes the first 30 amino acids of the protein product, was replaced with a neomycin selection cassette. The absence of transcript and protein in homozygous mutant mice was determined by Northern and Western blot analyses. (J:67358)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pdlim3 Mutation: 19 strains or lines available

References

• Original: J:67358 Jo K, et al., Actinin-associated LIM protein-deficient mice maintain normal development and structure of skeletal muscle. Mol Cell Biol. 2001 Mar;21(5):1682-7
• All: 2 reference(s)