Fosb^tm1Brv
Targeted Allele Detail

Summary

• Symbol: Fosb^tm1Brv
• Name: FBJ osteosarcoma oncogene B; targeted mutation 1, Rodrigo Bravo
• MGI ID: MGI:2385943
• Synonyms: fosB^-
• Gene: Fosb Location: Chr7:19036621-19043970 bp, - strand Genetic Position: Chr7, 9.56 cM, cytoband A2-B1
• Alliance: Fosb^tm1Brv page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:33415
• Parent Cell Line: D3 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The gene was disrupted by replacement of a 0.9 kb region including most of exon 2 to intron 3 (nucleotides 3460-4382) with a PGK-neo cassette via homologous recombination. Absence of gene expression in homozygous mutant animals was verified by immunohistochemical analysis of the serous glands. (J:33415)

Expression

In Mice Carrying this Mutation:

1 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Fosb Mutation: 22 strains or lines available

References

• Original: J:33415 Gruda MC, et al., Expression of FosB during mouse development: normal development of FosB knockout mice. Oncogene. 1996 May 16;12(10):2177-85
• All: 1 reference(s)