Nrf1^tm1Rcs
Targeted Allele Detail

Summary

• Symbol: Nrf1^tm1Rcs
• Name: nuclear respiratory factor 1; targeted mutation 1, Richard C Scarpulla
• MGI ID: MGI:2385947
• Gene: Nrf1 Location: Chr6:30047987-30153457 bp, + strand Genetic Position: Chr6, 12.47 cM
• Alliance: Nrf1^tm1Rcs page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:67376
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Sequence extending from within exon 2 to within exon 4 was replaced with a cassette containing the lacZ and neo genes. The deleted region encoded amino acids 86 through 166, which make up the nuclear localization signal and the DNA binding and dimerization domains. Expression of beta-galactosidase was determined to be driven by the endogenous promoter. (J:67376)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Nrf1 Mutation: 70 strains or lines available

References

• Original: J:67376 Huo L, et al., Mitochondrial DNA instability and peri-implantation lethality associated with targeted disruption of nuclear respiratory factor 1 in mice. Mol Cell Biol. 2001 Jan;21(2):644-54
• All: 1 reference(s)