Nfe2l2^tm1Ney
Targeted Allele Detail

Summary

• Symbol: Nfe2l2^tm1Ney
• Name: nuclear factor, erythroid derived 2, like 2; targeted mutation 1, Paul A Ney
• MGI ID: MGI:2385960
• Synonyms: Nrf-2 (-)
• Gene: Nfe2l2 Location: Chr2:75505857-75534985 bp, - strand Genetic Position: Chr2, 44.75 cM
• Alliance: Nfe2l2^tm1Ney page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:47440
• Parent Cell Line: RW-4 (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: A neomycin selection cassette was inserted into exon 5, into sequences encoding the BZIP domain. Northern blot analysis demonstrated that an aberrant transcript was expressed from this allele. However, immunoprecipitation experiments confirmed that no detectable protein was made. (J:47440)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Nfe2l2 Mutation: 90 strains or lines available

References

• Original: J:47440 Martin F, et al., Erythroid maturation and globin gene expression in mice with combined deficiency of NF-E2 and nrf-2. Blood. 1998 May 1;91(9):3459-66
• All: 3 reference(s)