Tcrg^tm1Ahay
Targeted Allele Detail

Summary

• Symbol: Tcrg^tm1Ahay
• Name: T cell receptor gamma chain; targeted mutation 1, Adrian Hayday
• MGI ID: MGI:2385961
• Synonyms: Vgamma5^-, Vr3^-
• Gene: Tcrg Location: Chr13:19362212-19540646 bp, + strand Genetic Position: Chr13, cytoband A2-A3

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:46358
• Parent Cell Line: Other (see notes) (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: The gene was disrupted by insertion of a PGK-neo cassette into exon 2 via homologous recombination. Absence of gene expression in homozygous mutant animals was confirmed by immunostaining of epidermal sheets using monoclonal antibodies to Tcrg-V5. (J:46358)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tcrg Mutation: 1 strain or line available

Notes

In the original reference the authors state that ES cell line was 129-Agouti.Sv.

References

• Original: J:46358 Mallick-Wood CA, et al., Conservation of T cell receptor conformation in epidermal gammadelta cells with disrupted primary Vgamma gene usage. Science. 1998 Mar 13;279(5357):1729-33
• All: 7 reference(s)