Epor^tm1.4Jtp
Targeted Allele Detail

Summary

• Symbol: Epor^tm1.4Jtp
• Name: erythropoietin receptor; targeted mutation 1.4, Josef T Prchal
• MGI ID: MGI:2386099
• Synonyms: Epor^Tr, mthEPOR
• Gene: Epor Location: Chr9:21870193-21874802 bp, - strand Genetic Position: Chr9, 7.93 cM
• Alliance: Epor^tm1.4Jtp page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:67205
• Parent Cell Line: HM-1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd-Hprt1^b-m3

Mutation description

• Allele Type: Targeted (Humanized sequence, Inserted expressed sequence)
• Mutations: Insertion, Intragenic deletion
• Epor^tm1.4Jtp expresses 1 gene
  Knock-in expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  EPOR (2057)

  Epor	(MGI:95408)

  C5964G transversion

• Mutation details: This allele is a derivative of Epor^tm1.3Jtp in which cre-mediated recombination in vivo removed the PGK-neo cassette in the germline. The resulting allele, Epor^tm1.4Jtp, contains human sequence carrying a C5964G transversion mutation in exon 8. RT-PCR analysis of bone marrow detected truncated human transcript in homozygous mutant mice. (J:67205)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Epor Mutation: 26 strains or lines available

References

• Original: J:67205 Divoky V, et al., Mouse model of congenital polycythemia: Homologous replacement of murine gene by mutant human erythropoietin receptor gene. Proc Natl Acad Sci U S A. 2001 Jan 30;98(3):986-91
• All: 6 reference(s)