Plcg2^tm1Jni
Targeted Allele Detail

Summary

• Symbol: Plcg2^tm1Jni
• Name: phospholipase C, gamma 2; targeted mutation 1, James N Ihle
• MGI ID: MGI:2386100
• Synonyms: PLCgamma2^-
• Gene: Plcg2 Location: Chr8:118225030-118361881 bp, + strand Genetic Position: Chr8, 64.26 cM
• Alliance: Plcg2^tm1Jni page

Plcg2^tm1Jni/Plcg2^tm1Jni mice are protected from mBSA-induced arthritis

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:63679
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A 3.8 kb region of the gene containing exon 2 was replaced with a neomycin resistance gene via homologous recombination. Spleen extracts from homozygous mutant animals did not contain protein product as determined by immunoprecipitation and Western blot analysis using antibodies directed against the C-terminus of the protein. (J:63679)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Plcg2 Mutation: 74 strains or lines available

References

• Original: J:63679 Wang D, et al., Phospholipase Cgamma2 is essential in the functions of B cell and several Fc receptors. Immunity. 2000 Jul;13(1):25-35
• All: 45 reference(s)