Rara^tm3Ipc
Targeted Allele Detail

Summary

• Symbol: Rara^tm3Ipc
• Name: retinoic acid receptor, alpha; targeted mutation 3, Pierre Chambon
• MGI ID: MGI:2386106
• Synonyms: RARalpha^fl, RARalpha L2
• Gene: Rara Location: Chr11:98818644-98865768 bp, + strand Genetic Position: Chr11, 62.76 cM, cytoband D-E1
• Alliance: Rara^tm3Ipc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:75135
• Parent Cell Line: D4 (ES Cell)
• Strain of Origin: 129/Sv

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: Exon 8, which encodes most of the DNA binding domain, was left flanked by loxP sites after the in vitro cre-mediated excision of a selection cassette. Immunohistochemical analysis showed that protein expression was not affected by the presence of the loxP sites. (J:75135)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rara Mutation: 79 strains or lines available

References

• Original: J:75135 Chapellier B, et al., A conditional floxed (loxP-flanked) allele for the retinoic acid receptor alpha (RARalpha) gene. Genesis. 2002 Feb;32(2):87-90
• All: 25 reference(s)