Rara^tm3.1Ipc
Targeted Allele Detail

Summary

• Symbol: Rara^tm3.1Ipc
• Name: retinoic acid receptor, alpha; targeted mutation 3.1, Pierre Chambon
• MGI ID: MGI:2386107
• Synonyms: RARalpha L^-
• Gene: Rara Location: Chr11:98818644-98865768 bp, + strand Genetic Position: Chr11, 62.76 cM, cytoband D-E1
• Alliance: Rara^tm3.1Ipc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:75135
• Parent Cell Line: D4 (ES Cell)
• Strain of Origin: 129/Sv

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: The floxed fragment containing exon 8 was excised from Rara^tm3Ipc by mating with mice carrying Tg(CMV-cre)1Ipc . The deletion eliminated the majority of the DNA binding domain and introduced a frameshift mutation. A lack of protein expression was demonstrated in homozygous mutant mice via immunohistochemical analysis of testis sections. (J:75135)

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rara Mutation: 79 strains or lines available

References

• Original: J:75135 Chapellier B, et al., A conditional floxed (loxP-flanked) allele for the retinoic acid receptor alpha (RARalpha) gene. Genesis. 2002 Feb;32(2):87-90
• All: 10 reference(s)