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Rarbtm2Ipc
Targeted Allele Detail
Summary
Symbol: Rarbtm2Ipc
Name: retinoic acid receptor, beta; targeted mutation 2, Pierre Chambon
MGI ID: MGI:2386108
Synonyms: RARbetaL2
Gene: Rarb  Location: Chr14:5650540-6038924 bp, + strand  Genetic Position: Chr14, 7.08 cM, cytoband A1-A3
Alliance: Rarbtm2Ipc page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:75134
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsExons 9 and 10, which encode amino acids 263 through 384 encompassing most of the ligand binding domain, were left flanked by loxP sites after the in vitro cre-mediated excision of a selection cassette. Both isoforms produced by the endogenous gene were detected in homozygous mutant mice, verifying that the presence of the loxP sites did not affect gene function. (J:75134)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 10 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Rarb Mutation:  40 strains or lines available
References
Original:  J:75134 Chapellier B, et al., A conditional floxed (loxP-flanked) allele for the retinoic acid receptor beta (RARbeta) gene. Genesis. 2002 Feb;32(2):91-4
All:  13 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory