Rarb^tm2.1Ipc
Targeted Allele Detail

Summary

• Symbol: Rarb^tm2.1Ipc
• Name: retinoic acid receptor, beta; targeted mutation 2.1, Pierre Chambon
• MGI ID: MGI:2386109
• Synonyms: RARbeta^L-
• Gene: Rarb Location: Chr14:5650540-6038924 bp, + strand Genetic Position: Chr14, 7.08 cM, cytoband A1-A3
• Alliance: Rarb^tm2.1Ipc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:75134
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: The floxed fragment containing exons 9 and and 10 was excised from Rarb^tm2Ipc by the ubiquitous in vivo expression of cre recombinase. The deletion eliminated the majority of the ligand binding domain and introduced a frameshift mutation. Neither isoform produced by the endogenous gene was detected in homozygous mutant mice via immunoblot analysis. (J:75134)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rarb Mutation: 40 strains or lines available

References

• Original: J:75134 Chapellier B, et al., A conditional floxed (loxP-flanked) allele for the retinoic acid receptor beta (RARbeta) gene. Genesis. 2002 Feb;32(2):91-4
• All: 2 reference(s)