Rarg^tm3.1Ipc
Targeted Allele Detail

Summary

• Symbol: Rarg^tm3.1Ipc
• Name: retinoic acid receptor, gamma; targeted mutation 3.1, Pierre Chambon
• MGI ID: MGI:2386112
• Synonyms: RARgamma^L-
• Gene: Rarg Location: Chr15:102143373-102165891 bp, - strand Genetic Position: Chr15, 57.4 cM, cytoband E-F3
• Alliance: Rarg^tm3.1Ipc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:75133
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: The floxed fragment containing exon 8 was excised from Rarg^tm3Ipc by the ubiquitous in vivo expression of cre recombinase. The deletion eliminated the majority of the DNA binding domain and introduced a frameshift mutation. A lack of protein expression was demonstrated in homozygous mutant mice via immunohistochemical analysis of skin sections. (J:75133)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rarg Mutation: 151 strains or lines available

References

• Original: J:75133 Chapellier B, et al., A conditional floxed (loxP-flanked) allele for the retinoic acid receptor gamma (RARgamma) gene. Genesis. 2002 Feb;32(2):95-8
• All: 4 reference(s)