Nkx6-1^tm1Jlr
Targeted Allele Detail

Summary

• Symbol: Nkx6-1^tm1Jlr
• Name: NK6 homeobox 1; targeted mutation 1, John L Rubenstein
• MGI ID: MGI:2386119
• Synonyms: Nkx6.1-
• Gene: Nkx6-1 Location: Chr5:101807050-101812577 bp, - strand Genetic Position: Chr5, 48.84 cM
• Alliance: Nkx6-1^tm1Jlr page

The gross morphology of Nkx6-1^tm1Jlr/Nkx6-1^tm1.2Msan embryos at E18.5

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:65594
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A portion of exon 1 including the translation initiation codon was replaced with a PGK-neo cassette via homologous recombination. (J:65594)

Expression

In Mice Carrying this Mutation:	2 assay results
In Structures Affected by this Mutation:	3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Nkx6-1 Mutation: 4 strains or lines available

References

• Original: J:65594 Sander M, et al., Homeobox gene Nkx6.1 lies downstream of Nkx2.2 in the major pathway of beta-cell formation in the pancreas. Development. 2000 Dec;127(24):5533-40
• All: 25 reference(s)