Piga^tm1Bsl
Targeted Allele Detail

Summary

• Symbol: Piga^tm1Bsl
• Name: phosphatidylinositol glycan anchor biosynthesis, class A; targeted mutation 1, Monica Bessler
• MGI ID: MGI:2386121
• Synonyms: lox-Piga-lacZ
• Gene: Piga Location: ChrX:163202814-163216912 bp, + strand Genetic Position: ChrX, 76.49 cM, cytoband F3-F4
• Alliance: Piga^tm1Bsl page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:75506
• Parent Cell Line: CJ7 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A 3' portion of exon 2 was flanked by loxP sites and immediately followed by an NLS-lacZ gene inserted into intron 2 such that cre mediated recombination will result in the expression of lacZ via the endogenous promoter. (J:75506)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Piga Mutation: 3 strains or lines available

References

• Original: J:75506 Tremml G, et al., Increased sensitivity to complement and a decreased red blood cell life span in mice mosaic for a nonfunctional Piga gene. Blood. 1999 Nov 1;94(9):2945-54
• All: 6 reference(s)