Gjc1^tm1Kwi
Targeted Allele Detail

Summary

• Symbol: Gjc1^tm1Kwi
• Name: gap junction protein, gamma 1; targeted mutation 1, Klaus Willecke
• MGI ID: MGI:2386124
• Synonyms: Cx45^-, Cx45lacZ
• Gene: Gjc1 Location: Chr11:102690405-102710526 bp, - strand Genetic Position: Chr11, 66.48 cM
• Alliance: Gjc1^tm1Kwi page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:64428
• Parent Cell Line: HM-1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd-Hprt1^b-m3

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: 663 bp of the gene just downstream of the start codon was replaced with a promoterless lacZ-neo cassette via homologous recombination. (J:64428)

Expression

In Mice Carrying this Mutation:	3 assay results
In Structures Affected by this Mutation:	1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Gjc1 Mutation: 33 strains or lines available

References

• Original: J:64428 Kruger O, et al., Defective vascular development in connexin 45-deficient mice. Development. 2000 Oct;127(19):4179-93
• All: 12 reference(s)