Hras^tm1Mok
Targeted Allele Detail

Summary

• Symbol: Hras^tm1Mok
• Name: Harvey rat sarcoma virus oncogene; targeted mutation 1, Moyota Katsuki
• MGI ID: MGI:2386128
• Synonyms: H-ras (-)
• Gene: Hras Location: Chr7:140770839-140773938 bp, - strand Genetic Position: Chr7, 86.48 cM
• Alliance: Hras^tm1Mok page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:62962
• Parent Cell Line: CCE/EK.CCE (ES Cell)
• Strain of Origin: 129S/SvEv-Gpi1^c

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The exons encoding the first 160 amino acids of the gene were replaced with a neomycin resistance cassette via homologous recombination. Skin lysates from homozygous mutant animals contained no detectable protein product as determined by Western blot analysis. (J:62962)

Expression

In Mice Carrying this Mutation:

2 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 15 strains available Cell Lines: 0 lines available
• Carrying any Hras Mutation: 30 strains or lines available

References

• Original: J:62962 Ise K, et al., Targeted deletion of the H-ras gene decreases tumor formation in mouse skin carcinogenesis. Oncogene. 2000 Jun 15;19(26):2951-6
• All: 6 reference(s)