Cd37^tm1Hor
Targeted Allele Detail

Summary

• Symbol: Cd37^tm1Hor
• Name: CD37 antigen; targeted mutation 1, Ivan Horak
• MGI ID: MGI:2386160
• Synonyms: CD37^-
• Gene: Cd37 Location: Chr7:44883056-44888539 bp, - strand Genetic Position: Chr7, 29.2 cM
• Alliance: Cd37^tm1Hor page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:63315
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Part of exon 3 and all of exon 4 were replaced with a PGK-neo cassette in the reverse orientation via homologous recombination. The gene targeting event results in deletion of part of the second transmembrane domain and the entire third transmembrane domain. Absence of gene expression in homozygous mutant animals was verified by Northern blot analysis of spleen mRNA using a Cd37 cDNA probe. (J:63315)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cd37 Mutation: 29 strains or lines available

References

• Original: J:63315 Knobeloch KP, et al., Targeted inactivation of the tetraspanin CD37 impairs T-cell-dependent B-cell response under suboptimal costimulatory conditions. Mol Cell Biol. 2000 Aug;20(15):5363-9
• All: 12 reference(s)