Hsd11b2^tm1Yko
Targeted Allele Detail

Summary

• Symbol: Hsd11b2^tm1Yko
• Name: hydroxysteroid 11-beta dehydrogenase 2; targeted mutation 1, Yuri V Kotelevtsev
• MGI ID: MGI:2386169
• Synonyms: 11Beta-HSD2^-
• Gene: Hsd11b2 Location: Chr8:106245387-106250620 bp, + strand Genetic Position: Chr8, 53.04 cM
• Alliance: Hsd11b2^tm1Yko page

Hyperplasia and hypertrophy of the distal renal tubular epithelium in Hsd11b2^tm1Yko/Hsd11b2^tm1Yko mice

Show the 2 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:53391
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 2 through 5 were replaced by a neomycin selection cassette. Transcript was undetected in homozygous mutant mice via Northern blot analysis of total kidney RNA. (J:53391)

Expression

In Mice Carrying this Mutation:	56 assay results
In Structures Affected by this Mutation:	7 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hsd11b2 Mutation: 19 strains or lines available

References

• Original: J:53391 Kotelevtsev Y, et al., Hypertension in mice lacking 11beta-hydroxysteroid dehydrogenase type 2. J Clin Invest. 1999 Mar;103(5):683-9
• All: 13 reference(s)