H1f3^tm1Mkk
Targeted Allele Detail

Summary

• Symbol: H1f3^tm1Mkk
• Name: H1.3 linker histone, cluster member; targeted mutation 1, Malathi K Kistler
• MGI ID: MGI:2386170
• Gene: H1f3 Location: Chr13:23739206-23739981 bp, + strand Genetic Position: Chr13, 9.79 cM, cytoband A2-A3
• Alliance: H1f3^tm1Mkk page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:67063
• Parent Cell Line: E14TG2a (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Disruption caused by insertion of vector
• Mutation details: A construct, in which a 0.5 Kb fragment extending from upstream of the TATA box through codon 117 was replaced with a neomycin selection cassette, was inserted at the endogenous locus via homologous recombination. No immunoreactivity was observed in testes sections obtained from homozygous mutant mice. (J:67063)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any H1f3 Mutation: 8 strains or lines available

References

• Original: J:67063 Fantz D, et al., Mice with a targeted disruption of the h1t gene are fertile and undergo normal changes in structural chromosomal proteins during spermiogenesis. Biol Reprod. 2001 Feb;64(2):425-31
• All: 1 reference(s)