Ttpa^tm1Hsz
Targeted Allele Detail

Summary

• Symbol: Ttpa^tm1Hsz
• Name: tocopherol (alpha) transfer protein; targeted mutation 1, Hiroshi Suzuki
• MGI ID: MGI:2386172
• Synonyms: alpha-TTP^-, alpha-Ttp^tm1Csk, Ttpa-
• Gene: Ttpa Location: Chr4:20007938-20030785 bp, + strand Genetic Position: Chr4, 7.76 cM, cytoband A3
• Alliance: Ttpa^tm1Hsz page

Histological findings indicating neurodegeneration in Ttpa^tm1Hsz/Ttpa^tm1Hsz mice

Show the 3 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:67046
• Parent Cell Line: Other (see notes) (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 1, containing the translational start codon, was replaced with a neomycin selection cassette. Transcript was undetected by Northern blot analysis of liver samples obtained from homozygous mutant mice. (J:67046)

Disease models

Expression

In Mice Carrying this Mutation:	11 assay results
In Structures Affected by this Mutation:	6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ttpa Mutation: 23 strains or lines available

Notes

ES cell lines = AB2.2 and A3-1. Mice from line L236 were derived from AB2.2 ES cells (129S7/SvEvBrd-Hprt^b-m2). Mice from line C229 were derived from A3-1 ES cells (129X1/SvJ).

References

• Original: J:67046 Jishage K, et al., Alpha-tocopherol transfer protein is important for the normal development of placental labyrinthine trophoblasts in mice. J Biol Chem. 2001 Jan 19;276(3):1669-72
• All: 14 reference(s)