Mmp12^tm1Sds
Targeted Allele Detail

Summary

• Symbol: Mmp12^tm1Sds
• Name: matrix metallopeptidase 12; targeted mutation 1, Steven D Shapiro
• MGI ID: MGI:2386174
• Synonyms: MME-, Mmp12^-, MMP-12-
• Gene: Mmp12 Location: Chr9:7344397-7360461 bp, + strand Genetic Position: Chr9, 2.46 cM
• Alliance: Mmp12^tm1Sds page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:32902
• Parent Cell Line: RW-4 (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The gene was disrupted by replacement of the majority of exon 2 with a PGK-neo cassette via homologous recombination. Gene transcription and protein production was absent in homozygous mutant animals as demonstrated by Northern and Western blot analysis of peritoneal macrophages and peritoneal fluid. (J:32902)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Mmp12 Mutation: 36 strains or lines available

References

• Original: J:32902 Shipley JM, et al., Metalloelastase is required for macrophage-mediated proteolysis and matrix invasion in mice. Proc Natl Acad Sci U S A. 1996 Apr 30;93(9):3942-6
• All: 70 reference(s)