S100b^tm1Daoh
Targeted Allele Detail

Summary

• Symbol: S100b^tm1Daoh
• Name: S100 protein, beta polypeptide, neural; targeted mutation 1, Alexander Marks
• MGI ID: MGI:2386179
• Synonyms: S100B-KO
• Gene: S100b Location: Chr10:76089687-76096993 bp, + strand Genetic Position: Chr10, 38.76 cM
• Alliance: S100b^tm1Daoh page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:62728
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 2 was replaced with a neomycin resistance gene via homologous recombination. Homozygous mutant animals did not express gene transcripts or protein products as determined by Northern and Western blot analysis of brain tissue. (J:62728)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any S100b Mutation: 15 strains or lines available

References

• Original: J:62728 Xiong Z, et al., Enhanced calcium transients in glial cells in neonatal cerebellar cultures derived from S100B null mice. Exp Cell Res. 2000 Jun 15;257(2):281-9
• All: 17 reference(s)