Zfpm2^tm1Sho
Targeted Allele Detail

Summary

• Symbol: Zfpm2^tm1Sho
• Name: zinc finger protein, multitype 2; targeted mutation 1, Stuart Orkin
• MGI ID: MGI:2386183
• Synonyms: Fog2-, FOG-2^-
• Gene: Zfpm2 Location: Chr15:40518438-40967988 bp, + strand Genetic Position: Chr15, 15.74 cM, cytoband C
• Alliance: Zfpm2^tm1Sho page

Abnormal lung development in the Zfpm2^tm1Sho/Zfpm2^tm1Sho mouse

Show the 8 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:62879
• Parent Cell Line: CJ7 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The gene was disrupted by replacement of sequences encoding all of the zinc finger motifs with a floxed neomycin-cytidine deaminase cassette. The floxed cassette was removed by crossing mutant animals to a cre deleter strain. Homozygous mutant embryos were detected by Southern blot analysis up to day E15.5. RNase protection assay showed an absence of Zfpm2 mRNA in hearts of E12.5 homozygous mutant embryos. (J:62879)

Disease models

Expression

In Mice Carrying this Mutation:	96 assay results 2 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	21 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Zfpm2 Mutation: 47 strains or lines available

References

• Original: J:62879 Tevosian SG, et al., FOG-2, a cofactor for GATA transcription factors, is essential for heart morphogenesis and development of coronary vessels from epicardium. Cell. 2000 Jun 23;101(7):729-39
• All: 15 reference(s)