Pdcd1^tm1Hon
Targeted Allele Detail

Summary

• Symbol: Pdcd1^tm1Hon
• Name: programmed cell death 1; targeted mutation 1, Tasuku Honjo
• MGI ID: MGI:2386184
• Synonyms: PD-1^-
• Gene: Pdcd1 Location: Chr1:93966027-93980278 bp, - strand Genetic Position: Chr1, 47.47 cM
• Alliance: Pdcd1^tm1Hon page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:50688
• Parent Cell Line: D3 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A region encoding both transmembrane and cytoplasmic domains was deleted by the replacement of sequence extending from within exon 3 through a portion of exon 4 with a neomycin selection cassette. Flow cytometric analysis of cultured cells derived from homozygous mutant mice showed a lack of protein expression on the cell surface. (J:50688)

Disease models

Expression

In Structures Affected by this Mutation:

10 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 6 strains available Cell Lines: 0 lines available
• Carrying any Pdcd1 Mutation: 97 strains or lines available

References

• Original: J:50688 Nishimura H, et al., Immunological studies on PD-1 deficient mice: implication of PD-1 as a negative regulator for B cell responses. Int Immunol. 1998 Oct;10(10):1563-72
• All: 131 reference(s)