Lyn^tm1Tya
Targeted Allele Detail

Summary

• Symbol: Lyn^tm1Tya
• Name: LYN proto-oncogene, Src family tyrosine kinase; targeted mutation 1, Tadashi Yamamoto
• MGI ID: MGI:2386196
• Synonyms: lyn^-
• Gene: Lyn Location: Chr4:3676865-3791613 bp, + strand Genetic Position: Chr4, 2.05 cM
• Alliance: Lyn^tm1Tya page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:29751
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: Exon 4, which encodes the amino terminal portion of the SH3 domain, was disrupted by the insertion of neomycin selection cassette. The absence of both isoforms was verified by Western blot analysis of spleen and cerebellum tissue obtained from homozygous mutant mice. (J:29751)

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Lyn Mutation: 65 strains or lines available

References

• Original: J:29751 Nishizumi H, et al., Impaired proliferation of peripheral B cells and indication of autoimmune disease in lyn-deficient mice. Immunity. 1995 Nov;3(5):549-60
• All: 23 reference(s)