Sdc4tm1Goe
Targeted Allele Detail
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Symbol: |
Sdc4tm1Goe |
Name: |
syndecan 4; targeted mutation 1, Paul F Goetinck |
MGI ID: |
MGI:2386199 |
Synonyms: |
S4-, Sdc4lacZ |
Gene: |
Sdc4 Location: Chr2:164266167-164285512 bp, - strand Genetic Position: Chr2, 85.16 cM
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Alliance: |
Sdc4tm1Goe page
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Germline Transmission: |
Earliest citation of germline transmission:
J:67007
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Parent Cell Line: |
J1 (ES Cell)
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Strain of Origin: |
129S4/SvJae
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Allele Type: |
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Targeted (Null/knockout) |
Mutations: |
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Insertion, Intragenic deletion
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Mutation details: Exons 1 through 3 were replaced by a cassette containing an IRES-beta-galactosidase and neo fusion gene. RT-PCR and flow cytometric analyses of skin fibroblasts confirmed the absence of normal transcript and the lack of protein surface expression in homozygous mutant mice. X-gal staining was not reported.
(J:67007)
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Key: |
hm |
homozygous |
ht |
heterozygous |
tg |
involves transgenes |
√ |
phenotype observed |
cn |
conditional genotype |
cx |
complex: > 1 genome feature |
ot |
other: hemizygous, indeterminate,... |
N |
normal phenotype |
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Genotype/ Background: |
| Allelic Composition | Genetic Background | Cell Line(s) |
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Loading... | | | involves: 129S4/SvJae * C57BL/6 | | | | involves: 129S4/SvJae * C57BL/6 | | | | involves: 129S4/SvJae * C57BL/6 * SJL | |
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Phenotypes: |
Affected Systems |
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cardiovascular system
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√
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decreased angiogenesis
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√
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√
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cellular
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√
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√
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decreased fibroblast cell migration
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√
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√
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homeostasis/metabolism
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√
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√
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delayed wound healing
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√
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√
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impaired wound healing
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√
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√
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muscle
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√
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increased skeletal muscle fiber size
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√
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increased skeletal muscle fiber diameter
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√
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increased skeletal muscle mass
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√
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increased skeletal muscle weight
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√
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Sdc4 Mutation: |
30 strains or lines available
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Original: |
J:67007 Echtermeyer F, et al., Delayed wound repair and impaired angiogenesis in mice lacking syndecan-4. J Clin Invest. 2001 Jan;107(2):R9-R14 |
All: |
28 reference(s) |
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