Sdc4^tm1Goe
Targeted Allele Detail

Summary

• Symbol: Sdc4^tm1Goe
• Name: syndecan 4; targeted mutation 1, Paul F Goetinck
• MGI ID: MGI:2386199
• Synonyms: S4^-, Sdc4^lacZ
• Gene: Sdc4 Location: Chr2:164266167-164285512 bp, - strand Genetic Position: Chr2, 85.16 cM
• Alliance: Sdc4^tm1Goe page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:67007
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 1 through 3 were replaced by a cassette containing an IRES-beta-galactosidase and neo fusion gene. RT-PCR and flow cytometric analyses of skin fibroblasts confirmed the absence of normal transcript and the lack of protein surface expression in homozygous mutant mice. X-gal staining was not reported. (J:67007)

Expression

In Mice Carrying this Mutation:

12 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Sdc4 Mutation: 30 strains or lines available

References

• Original: J:67007 Echtermeyer F, et al., Delayed wound repair and impaired angiogenesis in mice lacking syndecan-4. J Clin Invest. 2001 Jan;107(2):R9-R14
• All: 28 reference(s)