Nppb^tm1Yog
Targeted Allele Detail

Summary

• Symbol: Nppb^tm1Yog
• Name: natriuretic peptide type B; targeted mutation 1, Yoshihiro Ogawa
• MGI ID: MGI:2386215
• Synonyms: BNP^-, Nppb^-
• Gene: Nppb Location: Chr4:148070264-148071662 bp, + strand Genetic Position: Chr4, 78.57 cM
• Alliance: Nppb^tm1Yog page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:61680
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129/Sv

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The gene was disrupted by replacement of exons 1-2 with a neomycin resistance cassette via homologous recombination. Gene transcripts and protein product were not detectable in the hearts of homozygous mutant animals. (J:61680)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Nppb Mutation: 14 strains or lines available

References

• Original: J:61680 Tamura N, et al., Cardiac fibrosis in mice lacking brain natriuretic peptide. Proc Natl Acad Sci U S A. 2000 Apr 11;97(8):4239-44
• All: 2 reference(s)