Ptprz1^tm1Schl
Targeted Allele Detail

Summary

• Symbol: Ptprz1^tm1Schl
• Name: protein tyrosine phosphatase receptor type Z, polypeptide 1; targeted mutation 1, Joseph Schlessinger
• MGI ID: MGI:2386268
• Synonyms: RPTPBeta^-, RPTPbeta/zeta^-
• Gene: Ptprz1 Location: Chr6:22875501-23052915 bp, + strand Genetic Position: Chr6, 9.92 cM
• Alliance: Ptprz1^tm1Schl page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:64776
• Parent Cell Line: Other (see notes) (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin selection cassette inserted in the opposite orientation replaced exon 2 and precluded the translation of the carbonic anhydrase (CAH) domain. Transcript was undetected in homozygous mutant mice by Northern blot analysis of total brain RNA. (J:64776)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ptprz1 Mutation: 145 strains or lines available

Notes

ES cell line = R1 ((129X1/SvJ x 129S1/Sv)F1-Kitl⁺) or W4 (129S6/SvEvTac).

References

• Original: J:64776 Harroch S, et al., No obvious abnormality in mice deficient in receptor protein tyrosine phosphatase beta. Mol Cell Biol. 2000 Oct;20(20):7706-15
• All: 15 reference(s)