Chuk^tm1Ver
Targeted Allele Detail

Summary

• Symbol: Chuk^tm1Ver
• Name: conserved helix-loop-helix ubiquitous kinase; targeted mutation 1, Inder M Verma
• MGI ID: MGI:2386272
• Synonyms: IKK1^-
• Gene: Chuk Location: Chr19:44061774-44095919 bp, - strand Genetic Position: Chr19, 36.71 cM
• Alliance: Chuk^tm1Ver page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:55415
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A 3 kb region containing the promoter, exon 1, and part of intron 1 was replaced with a PGK-neo cassette via homologous recombination. The null allele was confirmed by Western blot analysis performed on primary embryonic fibroblasts cultured from homozygous mutant embryos. No protein expression was detected. (J:55415)

Disease models

Expression

In Mice Carrying this Mutation:	28 assay results
In Structures Affected by this Mutation:	19 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Chuk Mutation: 51 strains or lines available

References

• Original: J:55415 Li Q, et al., IKK1-deficient mice exhibit abnormal development of skin and skeleton. Genes Dev. 1999 May 15;13(10):1322-8
• All: 8 reference(s)