Slc6a2^tm1Mca
Targeted Allele Detail

Summary

• Symbol: Slc6a2^tm1Mca
• Name: solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2; targeted mutation 1, Marc G Caron
• MGI ID: MGI:2386278
• Synonyms: NET^-, NET KO
• Gene: Slc6a2 Location: Chr8:93687100-93728295 bp, + strand Genetic Position: Chr8, 44.99 cM
• Alliance: Slc6a2^tm1Mca page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:59663
• Parent Cell Line: AK7 (ES Cell)
• Strain of Origin: 129S4/SvJaeSor

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutation: Insertion
• Mutation details: The gene was disrupted by insertion of an enhanced green fluorescent protein (EGFP) gene and a PGK-neo cassette into exon 2 via homologous recombination. RT-PCR did not detect gene expression in adrenal glands of homozygous mutant animals. In addition, brain membranes from homozygous mutants showed no desipramine-binding activity. (J:59663, J:61825)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Slc6a2 Mutation: 35 strains or lines available

References

• Original: J:59663 Wang YM, et al., Genetic approaches to studying norepinephrine function: knockout of the mouse norepinephrine transporter gene. Biol Psychiatry. 1999 Nov 1;46(9):1124-30
• All: 28 reference(s)