Kat2b^tm1Roth
Targeted Allele Detail

Summary

• Symbol: Kat2b^tm1Roth
• Name: K(lysine) acetyltransferase 2B; targeted mutation 1, Sharon Y Roth
• MGI ID: MGI:2386280
• Synonyms: Pcaf-
• Gene: Kat2b Location: Chr17:53873889-53979748 bp, + strand Genetic Position: Chr17, 27.86 cM
• Alliance: Kat2b^tm1Roth page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:65002
• Parent Cell Line: AB1 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The exon 376 bp downstream of the translational start site was replaced by a cassette containing a polyA signal followed by a PGK-neo. An absence of transcript in homozygous mutant mice was determined by Northern blot analysis of a variety of tissues. (J:65002)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Kat2b Mutation: 153 strains or lines available

References

• Original: J:65002 Xu W, et al., Loss of gcn5l2 leads to increased apoptosis and mesodermal defects during mouse development. Nat Genet. 2000 Oct;26(2):229-32
• All: 5 reference(s)