Ivl^tm1Dji
Targeted Allele Detail

Summary

• Symbol: Ivl^tm1Dji
• Name: involucrin; targeted mutation 1, Philippe Djian
• MGI ID: MGI:2386285
• Synonyms: inv^-
• Gene: Ivl Location: Chr3:92478209-92481042 bp, - strand Genetic Position: Chr3, 40.14 cM
• Alliance: Ivl^tm1Dji page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:65192
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The entire coding region of the endogenous gene was replaced with a neomycin selection cassette via homologous recombination. Northern blot analysis of total RNA isolated from skin samples showed an absence of transcript in homozygous mutant mice. A lack of protein was confirmed by both Western blot analysis and in situ hybridization. (J:65192)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ivl Mutation: 32 strains or lines available

References

• Original: J:65192 Djian P, et al., Targeted ablation of the murine involucrin gene. J Cell Biol. 2000 Oct 16;151(2):381-8
• All: 5 reference(s)