Slpi^tm1Smw
Targeted Allele Detail

Summary

• Symbol: Slpi^tm1Smw
• Name: secretory leukocyte peptidase inhibitor; targeted mutation 1, Sharon M Wahl
• MGI ID: MGI:2386293
• Gene: Slpi Location: Chr2:164195990-164231015 bp, - strand Genetic Position: Chr2, 85.16 cM, cytoband H
• Alliance: Slpi^tm1Smw page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:65241
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Sequence extending from nucleotide -849 through nucleotide 46 was replaced with a neomycin selection cassette. Deletion of this region eliminated regulatory elements, sequence encoding the first 16 amino acids, and introduced a frameshift mutation. Northern blot analysis confirmed the absence of transcript in homozygous mutant mice. (J:65241)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Slpi Mutation: 17 strains or lines available

References

• Original: J:65241 Ashcroft GS, et al., Secretory leukocyte protease inhibitor mediates non-redundant functions necessary for normal wound healing. Nat Med. 2000 Oct;6(10):1147-53
• All: 10 reference(s)