Scgb1a1^tm1Abm
Targeted Allele Detail

Summary

• Symbol: Scgb1a1^tm1Abm
• Name: secretoglobin, family 1A, member 1; targeted mutation 1, Anil B Mukherjee
• MGI ID: MGI:2386295
• Synonyms: CC10-deficient, UG^-
• Gene: Scgb1a1 Location: Chr19:9061006-9065320 bp, - strand Genetic Position: Chr19, 6.05 cM, cytoband A
• Alliance: Scgb1a1^tm1Abm page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:40748
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A portion of exon 2 and all of exon 3 were replaced with a neomycin selection cassette. Transcript was undetected by RT-PCR analysis of total lung RNA obtained from homozygous mutant mice. The absence of protein was verified by Western blot analysis of lung lysates and immunohistochemical analysis of bronchiolar epithelial cells. Analysis of prostate and uterine tissue obtained from homozygous mutant mice yielded corroborative results. (J:40748)

Disease models

Expression

In Mice Carrying this Mutation:	1 assay results
In Structures Affected by this Mutation:	5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Scgb1a1 Mutation: 29 strains or lines available

References

• Original: J:40748 Zhang Z, et al., Severe fibronectin-deposit renal glomerular disease in mice lacking uteroglobin. Science. 1997 May 30;276(5317):1408-12
• All: 10 reference(s)