Gdf15^tm1Sjl
Targeted Allele Detail

Summary

• Symbol: Gdf15^tm1Sjl
• Name: growth differentiation factor 15; targeted mutation 1, Se-Jin Lee
• MGI ID: MGI:2386300
• Gene: Gdf15 Location: Chr8:71082043-71085106 bp, - strand Genetic Position: Chr8, 34.15 cM, cytoband C1
• Alliance: Gdf15^tm1Sjl page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:61788
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The gene was disrupted by replacement of exon 2 with a neomycin resistance cassette via homologous recombination. Exon 2 encodes the entire C-terminal domain of the protein. Homozygous mutant animals lack gene expression as demonstrated by Northern blot analysis of liver RNA using a probe to the C-terminal region of the gene. (J:61788)

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gdf15 Mutation: 27 strains or lines available

References

• Original: J:61788 Hsiao EC, et al., Characterization of growth-differentiation factor 15, a transforming growth factor beta superfamily member induced following liver injury. Mol Cell Biol. 2000 May;20(10):3742-51
• All: 35 reference(s)