Itga9^tm1Des
Targeted Allele Detail

Summary

• Symbol: Itga9^tm1Des
• Name: integrin alpha 9; targeted mutation 1, Dean Sheppard
• MGI ID: MGI:2386308
• Synonyms: alpha9^-
• Gene: Itga9 Location: Chr9:118435777-118730071 bp, + strand Genetic Position: Chr9, 70.32 cM
• Alliance: Itga9^tm1Des page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:63038
• Parent Cell Line: RF8 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: The gene was disrupted by insertion of a neomycin resistance cassette into exon 1 via homologous recombination. RT-PCR and Western blot analyses performed on liver homogenates from homozygous mutant animals did not detect gene transcripts or protein product. (J:63038)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Itga9 Mutation: 60 strains or lines available

References

• Original: J:63038 Huang XZ, et al., Fatal bilateral chylothorax in mice lacking the integrin alpha9beta1. Mol Cell Biol. 2000 Jul;20(14):5208-15
• All: 9 reference(s)