Kat2a^tm1Nkt
Targeted Allele Detail

Summary

• Symbol: Kat2a^tm1Nkt
• Name: K(lysine) acetyltransferase 2A; targeted mutation 1, Yoshihiro Nakatani
• MGI ID: MGI:2386309
• Synonyms: PCAF-B^-
• Gene: Kat2a Location: Chr11:100595572-100603291 bp, - strand Genetic Position: Chr11, 63.53 cM
• Alliance: Kat2a^tm1Nkt page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:65264
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin selection cassette replaced the genomic region encoding amino acids 472 through 830 of the carboxy terminus of the encoded protein. No protein product is expressed from this allele as determined by Western blot analysis. (J:65264)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Kat2a Mutation: 40 strains or lines available

References

• Original: J:65264 Yamauchi T, et al., Distinct but overlapping roles of histone acetylase PCAF and of the closely related PCAF-B/GCN5 in mouse embryogenesis. Proc Natl Acad Sci U S A. 2000 Oct 10;97(21):11303-6
• All: 2 reference(s)