Krt6a^tm1Der
Targeted Allele Detail

Summary

• Symbol: Krt6a^tm1Der
• Name: keratin 6A; targeted mutation 1, Dennis R Roop
• MGI ID: MGI:2386313
• Synonyms: MK6a^-
• Gene: Krt6a Location: Chr15:101598363-101602746 bp, - strand Genetic Position: Chr15, 56.97 cM
• Alliance: Krt6a^tm1Der page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:63037
• Parent Cell Line: AB2.2 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1^b-m2

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The entire coding region of the gene was replaced with a neomycin resistance cassette, Hprt minigene, and loxP site. Homozygous mutant animals lacked gene expression and protein production as shown by RNase protection assay and Western blot analysis of whole skin samples, respectively. (J:63037)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Krt6a Mutation: 25 strains or lines available

References

• Original: J:63037 Wojcik SM, et al., Delayed wound healing in keratin 6a knockout mice. Mol Cell Biol. 2000 Jul;20(14):5248-55
• All: 1 reference(s)