Gata5^tm1Eno
Targeted Allele Detail

Summary

• Symbol: Gata5^tm1Eno
• Name: GATA binding protein 5; targeted mutation 1, Eric N Olson
• MGI ID: MGI:2386318
• Synonyms: GATA5-
• Gene: Gata5 Location: Chr2:179966926-179976492 bp, - strand Genetic Position: Chr2, 102.85 cM
• Alliance: Gata5^tm1Eno page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:63036
• Parent Cell Line: KG-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 1 encoding amino acids 1-157 was replaced with a PGK-neo cassette via homologous recombination. Homozygous mutant animals lacked gene expression as demonstrated by RT-PCR analysis of RNA from the large intestine. (J:63036)

Expression

In Structures Affected by this Mutation:

12 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gata5 Mutation: 17 strains or lines available

References

• Original: J:63036 Molkentin JD, et al., Abnormalities of the genitourinary tract in female mice lacking GATA5. Mol Cell Biol. 2000 Jul;20(14):5256-60
• All: 1 reference(s)