Rev3l^tm1Rwd
Targeted Allele Detail

Summary

• Symbol: Rev3l^tm1Rwd
• Name: REV3 like, DNA directed polymerase zeta catalytic subunit; targeted mutation 1, Richard D Wood
• MGI ID: MGI:2386322
• Synonyms: Rev3l-
• Gene: Rev3l Location: Chr10:39608114-39751207 bp, + strand Genetic Position: Chr10, 21.04 cM
• Alliance: Rev3l^tm1Rwd page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:65201
• Parent Cell Line: GK129 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Two exons encoding a portion of polymerase motif 1 and all of polymerase motif 5 were replaced with a bicistronic cassette containing a splice acceptor site and IRES immediately upstream of a promoterless lacZ and neo fusion gene. Expression of beta-galactosidase was observed by staining mutant embryos. (J:65201)

Expression

In Structures Affected by this Mutation:

7 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rev3l Mutation: 120 strains or lines available

References

• Original: J:65201 Wittschieben J, et al., Disruption of the developmentally regulated rev3l gene causes embryonic lethality. Curr Biol. 2000 Oct 5;10(19):1217-20
• All: 7 reference(s)