Igf1rtm1Mhz
Targeted Allele Detail
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Symbol: |
Igf1rtm1Mhz |
Name: |
insulin-like growth factor I receptor; targeted mutation 1, Martin Holzenberger |
MGI ID: |
MGI:2386327 |
Synonyms: |
IGF-IRneo |
Gene: |
Igf1r Location: Chr7:67602575-67883416 bp, + strand Genetic Position: Chr7, 37.27 cM
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Alliance: |
Igf1rtm1Mhz page
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Germline Transmission: |
Earliest citation of germline transmission:
J:63460
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Parent Cell Line: |
Not Specified (ES Cell)
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Strain of Origin: |
129/Sv
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Allele Type: |
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Targeted (Null/knockout) |
Mutation: |
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Insertion
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Mutation details: Exon 3 was flanked by a floxed neo cassette inserted into intron 2 and a single loxP site in intron 3. Several aberrant transcripts involving the splicing of exon 2 to cryptic slice sites in the neo transgene were identified by RT-PCR and sequence analyses. Further analysis indicated that the readthrough of the neo transgene will result in functional ablation due to truncation or the inclusion of a random neo fragment. Mice carrying this allele were crossed with transgenic mice expressing cre recombinase via the EIIa promoter to generate Igf1rtm1.1Mhz and Igf1rtm1.2Mhz.
(J:63460)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Igf1r Mutation: |
85 strains or lines available
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Original: |
J:63460 Holzenberger M, et al., A targeted partial invalidation of the insulin-like growth factor I receptor gene in mice causes a postnatal growth deficit. Endocrinology. 2000 Jul;141(7):2557-66 |
All: |
6 reference(s) |
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