Smad4^tm2Cxd
Targeted Allele Detail

Summary

• Symbol: Smad4^tm2Cxd
• Name: SMAD family member 4; targeted mutation 2, Chu-Xia Deng
• MGI ID: MGI:2386390
• Synonyms: Smad4^neo-Co
• Gene: Smad4 Location: Chr18:73772080-73836851 bp, - strand Genetic Position: Chr18, 49.51 cM
• Alliance: Smad4^tm2Cxd page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:75140
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: Exon 8 was flanked by a single loxP site in intron 7 and a floxed neo cassette in intron 8. The presence of the neo cassette was found to interfere with normal splicing, resulting in lethality of homozygous embryos. Mice carrying this allele were bred with mice expressing cre recombinase via the EIIa promoter to excise either the neo cassette or the neo cassette and exon 8 together. (J:75140)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Smad4 Mutation: 48 strains or lines available

References

• Original: J:75140 Yang X, et al., Generation of Smad4/Dpc4 conditional knockout mice. Genesis. 2002 Feb;32(2):80-1
• All: 1 reference(s)