Renbp^tm1Csch
Targeted Allele Detail

Summary

• Symbol: Renbp^tm1Csch
• Name: renin binding protein; targeted mutation 1, Christian Schmitz
• MGI ID: MGI:2386397
• Synonyms: RnBP^-
• Gene: Renbp Location: ChrX:72965727-72974408 bp, - strand Genetic Position: ChrX, 37.49 cM
• Alliance: Renbp^tm1Csch page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:62268
• Parent Cell Line: Other (see notes) (ES Cell)
• Strain of Origin: 129/SvEmcTer

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The gene was disrupted by replacement of a 1 kb region including part of exon 5 and exon 6 with a neomycin resistance cassette via homologous recombination. The targeted mutation results in deletion of sequences encoding a leucine zipper motif, which is required for interaction with renin. Homozygous mutant animals did not express gene transcripts as determined by Northern blot analysis of kidney RNA. (J:62268)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Renbp Mutation: 5 strains or lines available

Notes

ES cell line = ICp4.

References

• Original: J:62268 Schmitz C, et al., Normal blood pressure and plasma renin activity in mice lacking the renin-binding protein, a cellular renin inhibitor. J Biol Chem. 2000 May 19;275(20):15357-62
• All: 1 reference(s)