Xist^tm1Nbd
Targeted Allele Detail

Summary

• Symbol: Xist^tm1Nbd
• Name: inactive X specific transcripts; targeted mutation 1, Neil Brockdorff
• MGI ID: MGI:2386402
• Synonyms: Xist^{delta hs}
• Gene: Xist Location: ChrX:102503979-102526839 bp, - strand Genetic Position: ChrX, 46.15 cM, cytoband D
• Alliance: Xist^tm1Nbd page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:68080
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Two DNAse1 hypersensitive sites (HS3 and HS4) located upstream of the first promoter at the endogenous locus were replaced with a floxed neo cassette via homologous recombination. (J:68080)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Xist Mutation: 8 strains or lines available

References

• Original: J:68080 Newall AE, et al., Primary non-random X inactivation associated with disruption of Xist promoter regulation. Hum Mol Genet. 2001 Mar 15;10(6):581-9
• All: 5 reference(s)